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Thomas K. Shimotake


  • Professor, Pediatrics
  • Associate Director of Clinical Programs in Neonatology
  • Co-Director, Neuro-Intensive Care Nursery
  • Fellowship Director, Neonatal-Perinatal Medicine


Dr. Thomas Shimotake currently serves as Associate Director of Clinical Programs in Neonatology at UCSF. Dr. Shimotake earned his medical degree from the University of Illinois at Chicago in 1997. He had previously completed a two-year research assistantship at the National Institute of Mental Health, in the Division of Neuroscience, studying the pharmacokinetics of neuroleptic agents. He then completed his Pediatric internship, residency and sub-specialty fellowship training in Neonatal-Perinatal Medicine at the University of Chicago Children’s Hospital. During this time, Dr. Shimotake investigated the mechanisms of airway inflammation from tracheal aspirates of premature infants on mechanical ventilation, under the mentorship of Dr. Marc Hershenson. He also received multiple awards from residents and students in recognition of excellence in teaching.

He joined the faculty as an Instructor in the Department of Pediatrics at the University of California San Francisco in 2003, researching the role of surfactant proteins in neonatal lung homeostasis, under the mentorship of Dr. Sam Hawgood. His current appointment is as HS Assistant Clinical Professor of Pediatrics and he has continued to play an active role in both resident and fellow education. In 2007, he was named Fellowship Director for the Neonatal-Perinatal Medicine Training Program at UCSF. In 2008, Dr. Shimotake also began serving as Co-Director of the UCSF Neuro-Intensive Care Nursery, which is the first unit of it’s kind in the world.

Dr. Shimotake is a Fellow of the American Academy of Pediatrics and holds memberships in a number of other medical societies and associations. He has played an active role in efforts at both Outreach education and in developing standards for the implementation of therapeutic hypothermia (cooling) after birth asphyxia. He has made numerous presentations to regional hospitals and organizations overseeing the care and transport of Neonates at risk for injury after birth asphyxia.

Education & Training

  • University of Illinois School of Medicine


  • Blauvelt CA, Chiu C, Donovan AL, Prahl M, Shimotake TK, George RB, Schwartz BS, Farooqi NA, Ali SS, Cassidy A, Gonzalez JM, Gaw SL. Acute Respiratory Distress Syndrome in a Preterm Pregnant Patient With Coronavirus Disease 2019 (COVID-19). Obstet Gynecol. 2020 07; 136(1):46-51. PubMed
  • Glass HC, Ferriero DM, Rowitch DH, Shimotake TK. The neurointensive nursery: concept, development, and insights gained. Curr Opin Pediatr. 2019 04; 31(2):202-209. PubMed
  • Cornet MC, Pasupuleti A, Fang A, Gonzalez F, Shimotake T, Ferriero DM, Glass HC, Cilio MR. Predictive value of early EEG for seizures in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia. Pediatr Res. 2018 09; 84(3):399-402. PubMed
  • Wusthoff CJ, Clark CL, Glass HC, Shimotake TK, Schulman J, Bonifacio SL. Cooling in neonatal hypoxic-ischemic encephalopathy: practices and opinions on minimum standards in the state of California. J Perinatol. 2018 01; 38(1):54-58. PubMed
  • Mrelashvili A, Bonifacio SL, Rogers EE, Shimotake TK, Glass HC. Outcome After Therapeutic Hypothermia in Term Neonates With Encephalopathy and a Syndromic Diagnosis. J Child Neurol. 2015 Oct; 30(11):1453-8. PubMed
  • Akula VP, Joe P, Thusu K, Davis AS, Tamaresis JS, Kim S, Shimotake TK, Butler S, Honold J, Kuzniewicz M, DeSandre G, Bennett M, Gould J, Wallenstein MB, Van Meurs K. A randomized clinical trial of therapeutic hypothermia mode during transport for neonatal encephalopathy. J Pediatr. 2015 Apr; 166(4):856-61.e1-2. PubMed
  • Shue EH, Soares B, Courtier J, Hogue J, Shimotake T, MacKenzie TC. Type IV intestinal atresia, congenital bilateral perisylvian syndrome, and chronic pulmonary hypertension secondary to multiple vascular disruption syndrome in a monochorionic twin. J Pediatr Surg. 2012 Oct; 47(10):1938-42. PubMed
  • Glass HC, Bonifacio SL, Shimotake T, Ferriero DM. Neurocritical care for neonates. Curr Treat Options Neurol. 2011 Dec; 13(6):574-89. PubMed
  • Hogeling M, Meddles K, Berk DR, Bruckner AL, Shimotake TK, Cohen RS, Frieden IJ. Extensive subcutaneous fat necrosis of the newborn associated with therapeutic hypothermia. Pediatr Dermatol. 2012 Jan-Feb; 29(1):59-63. PubMed
  • Glass HC, Bonifacio SL, Peloquin S, Shimotake T, Sehring S, Sun Y, Sullivan J, Rogers E, Barkovich AJ, Rowitch D, Ferriero DM. Neurocritical care for neonates. Neurocrit Care. 2010 Jun; 12(3):421-9. PubMed
  • Baldán A, Tarr P, Vales CS, Frank J, Shimotake TK, Hawgood S, Edwards PA. Deletion of the transmembrane transporter ABCG1 results in progressive pulmonary lipidosis. J Biol Chem. 2006 Sep 29; 281(39):29401-10. PubMed
  • Shimotake TK, Izhar FM, Rumilla K, Li J, Tan A, Page K, Brasier AR, Schreiber MD, Hershenson MB. Interleukin (IL)-1 beta in tracheal aspirates from premature infants induces airway epithelial cell IL-8 expression via an NF-kappa B dependent pathway. Pediatr Res. 2004 Dec; 56(6):907-13. PubMed
  • Yanagihara J, Nakamura K, Shimotake T, Deguchi E, Iwai N. An association of multiple intestinal atresia and biliary atresia: a case report. Eur J Pediatr Surg. 1995 Dec; 5(6):372-4. PubMed
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