Teresa Sparks

MD

  • Assistant Professor, Ob/Gyn, Reproductive Sciences
  • Perinatologist and Medical Geneticist

Biography

Dr. Teresa Sparks is an obstetrician and gynecologist who specializes in high-risk pregnancies and perinatal genetics. She has particular interests in fetal anomalies, management of pregnancies affected by maternal or fetal genetic conditions, and prenatal diagnosis. Dr. Sparks has research interests focused onĀ theĀ genetic etiologies underlying non-immune hydrops fetalis, as well as on prenatal diagnosis of fetal genetic conditions and perinatal management of these pregnancies.

Dr. Sparks completed her medical degree at the University of California, San Francisco School of Medicine. She completed her internship and residency in the combinedĀ Obstetrics and Gynecology program at Brigham & Women's Hospital and Massachusetts General Hospital. She thenĀ returned to UCSF to completeĀ a dual fellowship in Maternal-Fetal Medicine and Clinical Genetics, after which she joinedĀ the faculty at UCSF in Maternal-Fetal Medicine and Clinical Genetics.

Dr. Sparks is board certified in both Obstetrics & Gynecology and Clinical Genetics.

Education & Training

  • University of California, San Francisco , San Francisco

    Clinical Research

  • University of California, San Francisco , San Francisco

    Maternal Fetal Medicine and Clinical Genetics

  • Brigham & Women's Hospital/Massachusetts General Hospital , Boston

    Obstetrics & Gynecology

  • University of California, San Francisco , San Francisco

    Medicine

Clincial Trials

Research Activities & Funding

  • Sponsor: Chan Zuckerberg Biohub Investigator Program

    Role: PI

  • Sponsor: NIH/NICHD R01HD107190

    Role: PI

  • Sponsor: Doris Duke Charitable Foundation

    Role: PI

  • Sponsor: NICHD/NIH 5K12 HD001262

    Role:

  • Sponsor: Fetal Health Foundation Brianna Marie Memorial Research Grant

    Role: PI

  • Sponsor: Fetal Health Foundation Brianna Marie Memorial Research Grant

    Role: PI

Publications

  • Jelin AC, Mahle A, Tran SH, Sparks TN, Rauen KA. Obstetrical and neonatal outcomes of cardio-facio-cutaneous syndrome: Prenatal consequences of Ras/MAPK dysregulation. Am J Med Genet A. 2022 Oct 29. PubMed

  • Herzeg A, Almeida-Porada G, Charo RA, David AL, Gonzalez-Velez J, Gupta N, Lapteva L, Lianoglou B, Peranteau W, Porada C, Sanders SJ, Sparks TN, Stitelman DH, Struble E, Sumner CJ, MacKenzie TC. Prenatal Somatic Cell Gene Therapies: Charting a Path Toward Clinical Applications (Proceedings of the CERSI-FDA Meeting). J Clin Pharmacol. 2022 09; 62 Suppl 1:S36-S52. PubMed

  • Sparks TN, Dugoff L. How to choose a test for prenatal genetic diagnosis: a practical overview. Am J Obstet Gynecol. 2022 Aug 24. PubMed

  • Avram CM, Caughey AB, Norton ME, Sparks TN. Cost-Effectiveness of Exome Sequencing versus Targeted Gene Panels for Prenatal Diagnosis of Fetal Effusions and Non-Immune Hydrops Fetalis. Am J Obstet Gynecol MFM. 2022 Aug 19; 4(6):100724. PubMed

  • Dhombres F, Morgan P, Chaudhari BP, Filges I, Sparks TN, Lapunzina P, Roscioli T, Agarwal U, Aggarwal S, Beneteau C, Cacheiro P, Carmody LC, Collardeau-Frachon S, Dempsey EA, Dufke A, Duyzend MH, El Ghosh M, Giordano JL, Glad R, Grinfelde I, Iliescu DG, Ladewig MS, Munoz-Torres MC, Pollazzon M, Radio FC, Rodo C, Silva RG, Smedley D, Sundaramurthi JC, Toro S, Valenzuela I, Vasilevsky NA, Wapner RJ, Zemet R, Haendel MA, Robinson PN. Prenatal phenotyping: A community effort to enhance the Human Phenotype Ontology. Am J Med Genet C Semin Med Genet. 2022 Jul 24. PubMed

  • Swanson K, Norton ME, Lianoglou BR, Jelin AC, Hodoglugil U, Van Ziffle J, Devine P, Sparks TN. The utility of pathologic examination and comprehensive phenotyping for accurate diagnosis with perinatal exome sequencing. Prenat Diagn. 2022 09; 42(10):1288-1294. PubMed

  • Brown JEH, Zamora AN, Outram S, Sparks TN, Lianoglou BR, Norstad M, Sahin Hodoglugil NN, Norton ME, Ackerman SL. "Let's Just Wait Until She's Born": Temporal Factors That Shape Decision-Making for Prenatal Genomic Sequencing Amongst Families Underrepresented in Genomic Research. Front Genet. 2022; 13:882703. PubMed

  • Rego S, Hoban H, Outram S, Zamora AN, Chen F, Sahin-Hodoglugil N, Anguiano B, Norstad M, Yip T, Lianoglou B, Sparks TN, Norton ME, Koenig BA, Slavotinek AM, Ackerman SL. Perspectives and preferences regarding genomic secondary findings in underrepresented prenatal and pediatric populations: A mixed-methods approach. Genet Med. 2022 06; 24(6):1206-1216. PubMed

  • Swanson K, Loeliger KB, Chetty SP, Sparks TN, Norton ME. Disparities in the acceptance of chromosomal microarray at the time of prenatal genetic diagnosis. Prenat Diagn. 2022 05; 42(5):611-616. PubMed

  • Slavotinek A, Lefebvre M, Brehin AC, Thauvin C, Patrier S, Sparks TN, Norton M, Yu J, Huang E. Prenatal presentation of multiple anomalies associated with haploinsufficiency for ARID1A. Eur J Med Genet. 2022 Feb; 65(2):104407. PubMed

  • Swanson K, Bishop JC, Al-Kouatly HB, Makhamreh M, Felton T, Vora NL, Sparks TN, Jelin AC. Prenatal phenotype of 47, XXY (Klinefelter syndrome). Prenat Diagn. 2021 Dec 07. PubMed

  • Sparks TN. The Current State and Future of Fetal Therapies. Clin Obstet Gynecol. 2021 12 01; 64(4):926-932. PubMed

  • Norton ME, Sparks TN. Response to "Further genetic testing in prenatal cases of nonimmune hydrops fetalis with a normal array: a targeted panel or exome?" Am J Obstet Gynecol. 2022 02; 226(2):277. PubMed

  • Gregg AR, Aarabi M, Klugman S, Leach NT, Bashford MT, Goldwaser T, Chen E, Sparks TN, Reddi HV, Rajkovic A, Dungan JS, ACMG Professional Practice and Guidelines Committee. Correction to: Screening for autosomal recessive and X-linked conditions during pregnancy and preconception: a practice resource of the American College of Medical Genetics and Genomics (ACMG). Genet Med. 2021 Oct; 23(10):2015. PubMed

  • Mone F, Eberhardt RY, Hurles ME, Mcmullan DJ, Maher ER, Lord J, Chitty LS, Dempsey E, Homfray T, Giordano JL, Wapner RJ, Sun L, Sparks TN, Norton ME, Kilby MD. Fetal hydrops and the Incremental yield of Next-generation sequencing over standard prenatal Diagnostic testing (FIND) study: prospective cohort study and meta-analysis. Ultrasound Obstet Gynecol. 2021 Oct; 58(4):509-518. PubMed

  • Society for Maternal-Fetal Medicine (SMFM), Sparks TN. Hypospadias. Am J Obstet Gynecol. 2021 11; 225(5):B18-B20. PubMed

  • Norton ME, Ziffle JV, Lianoglou BR, Hodoglugil U, Devine WP, Sparks TN. Exome sequencing vs targeted gene panels for the evaluation of nonimmune hydrops fetalis. Am J Obstet Gynecol. 2022 01; 226(1):128.e1-128.e11. PubMed

  • Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.org, Norton ME, Cheng Y, Chetty S, Chyu JK, Connolly K, Ghaffari N, Hopkins LM, Jelin A, Mardy A, Osmundson SS, Sparks TN, Sperling J, Swanson K, Zuckerwise LC, Kuller JA. SMFM Fetal Anomalies Consult Series #4: Genitourinary anomalies. Am J Obstet Gynecol. 2021 11; 225(5):B2-B35. PubMed

  • Gregg AR, Aarabi M, Klugman S, Leach NT, Bashford MT, Goldwaser T, Chen E, Sparks TN, Reddi HV, Rajkovic A, Dungan JS, ACMG Professional Practice and Guidelines Committee. Screening for autosomal recessive and X-linked conditions during pregnancy and preconception: a practice resource of the American College of Medical Genetics and Genomics (ACMG). Genet Med. 2021 10; 23(10):1793-1806. PubMed

  • Yeaton-Massey A, Sparks TN, Norton ME, Jelliffe-Pawlowski L, Currier RJ. Twin chorionicity and zygosity both vary with maternal age. Prenat Diagn. 2021 08; 41(9):1074-1079. PubMed

  • Swanson K, Sparks TN, Lianoglou BR, Chen F, Downum S, Patel S, Rego S, Yip T, Van Ziffle J, Koenig BA, Slavotinek AM, Norton ME. Preference for secondary findings in prenatal and pediatric exome sequencing. Prenat Diagn. 2022 05; 42(6):753-761. PubMed

  • Zhang-Rutledge K, Jacobs M, Patberg E, Field N, Holliman K, Strobel KM, Murphy A, Robles D, Rangwala N, Gonzalez JM, Sparks TN, University of California Fetal-Maternal Consortium. Interval growth across gestation in pregnancies with fetal gastroschisis. Am J Obstet Gynecol MFM. 2021 09; 3(5):100415. PubMed

  • Sobhani NC, Sparks TN, Gosnell KA, Rand L, Gonzalez JM, Feldstein VA. Outcomes of Monochorionic, Diamniotic Twin Pregnancies with Prenatally Diagnosed Intertwin Weight Discordance. Am J Perinatol. 2021 06; 38(7):649-656. PubMed

  • Sparks TN, Lianoglou BR, Adami RR, Pluym ID, Holliman K, Duffy J, Downum SL, Patel S, Faubel A, Boe NM, Field NT, Murphy A, Laurent LC, Jolley J, Uy C, Slavotinek AM, Devine P, Hodoglugil U, Van Ziffle J, Sanders SJ, MacKenzie TC, Norton ME, University of California Fetalā€“Maternal Consortium, University of California, San Francisco Center for Maternalā€“Fetal Precision Medicine. Exome Sequencing for Prenatal Diagnosis in Nonimmune Hydrops Fetalis. N Engl J Med. 2020 10 29; 383(18):1746-1756. PubMed

  • Mardy AH, Wiita AP, Wayman BV, Drexler K, Sparks TN, Norton ME. Variants of uncertain significance in prenatal microarrays: a retrospective cohort study. BJOG. 2021 01; 128(2):431-438. PubMed

  • Jelin AC, Sobreira N, Wohler E, Solomon B, Sparks T, Sagaser KG, Forster KR, Miller J, Witmer PD, Hamosh A, Valle D, Blakemore K. The utility of exome sequencing for fetal pleural effusions. Prenat Diagn. 2020 04; 40(5):590-595. PubMed

  • Mardy AH, Rangwala N, Hernandez-Cruz Y, Gosnell KA, Gonzalez JM, Norton ME, Sparks TN. Utility of chromosomal microarray for diagnosis in cases of nonimmune hydrops fetalis. Prenat Diagn. 2020 03; 40(4):492-496. PubMed

  • Berger VK, Norton ME, Sparks TN, Flessel M, Baer RJ, Currier RJ. The utility of nuchal translucency ultrasound in identifying rare chromosomal abnormalities not detectable by cell-free DNA screening. Prenat Diagn. 2020 01; 40(2):185-190. PubMed

  • Sparks TN. Expanded carrier screening: counseling and considerations. Hum Genet. 2020 Sep; 139(9):1131-1139. PubMed

  • Avram CM, Shaffer BL, Sparks TN, Allen AJ, Caughey AB. Cell-free fetal DNA screening for detection of microdeletion syndromes: a cost-effectiveness analysis. J Matern Fetal Neonatal Med. 2021 Jun; 34(11):1732-1740. PubMed

  • Mardy AH, Chetty SP, Norton ME, Sparks TN. A system-based approach to the genetic etiologies of non-immune hydrops fetalis. Prenat Diagn. 2019 08; 39(9):732-750. PubMed

  • Sparks TN, Thao K, Lianoglou BR, Boe NM, Bruce KG, Datkhaeva I, Field NT, Fratto VM, Jolley J, Laurent LC, Mardy AH, Murphy AM, Ngan E, Rangwala N, Rottkamp CAM, Wilson L, Wu E, Uy CC, Valdez Lopez P, Norton ME, University of California Fetalā€“Maternal Consortium (UCfC). Nonimmune hydrops fetalis: identifying the underlying genetic etiology. Genet Med. 2019 06; 21(6):1339-1344. PubMed

  • Shulman R, Sparks TN, Gosnell K, Blat C, Norton ME, Lee H, Gonzalez-Velez J, Goldstein RB. Fetal Congenital Pulmonary Airway Malformation: The Role of an Objective Measurement of Cardiomediastinal Shift. Am J Perinatol. 2019 02; 36(3):225-232. PubMed

  • Sparks TN, Caughey AB. How should costs and cost-effectiveness be considered in prenatal genetic testing? Semin Perinatol. 2018 08; 42(5):275-282. PubMed

  • Washburn EE, Sparks TN, Gosnell KA, Rand L, Gonzalez JM, Feldstein VA. Stage I Twin-Twin Transfusion Syndrome: Outcomes of Expectant Management and Prognostic Features. Am J Perinatol. 2018 12; 35(14):1352-1357. PubMed

  • Sperling JD, Sparks TN, Berger VK, Farrell JA, Gosnell K, Keller RL, Norton ME, Gonzalez JM. Prenatal Diagnosis of Congenital Diaphragmatic Hernia: Does Laterality Predict Perinatal Outcomes? Am J Perinatol. 2018 08; 35(10):919-924. PubMed

  • Parchem JG, Sparks TN, Gosnell K, Norton ME. Utility of chromosomal microarray in anomalous fetuses. Prenat Diagn. 2018 01; 38(2):140-147. PubMed

  • Washburn EE, Sparks TN, Gosnell KA, Rand L, Gonzalez JM, Feldstein VA. Polyhydramnios Affecting a Recipient-like Twin: Risk of Progression to Twin-Twin Transfusion Syndrome and Outcomes. Am J Perinatol. 2018 03; 35(4):317-323. PubMed

  • Berger VK, Sparks TN, Jelin AC, Derderian C, Jeanty C, Gosnell K, Mackenzie T, Gonzalez JM. Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter? J Ultrasound Med. 2018 May; 37(5):1185-1191. PubMed

  • Pilliod RA, Page JM, Sparks TN, Caughey AB. The growth-restricted fetus: risk of mortality by each additional week of expectant management. J Matern Fetal Neonatal Med. 2019 Feb; 32(3):442-447. PubMed

  • Zahed H, Sparks TN, Li B, Alsadah A, Shieh JTC. Potential Role of Genomic Sequencing in the Early Diagnosis of Treatable Genetic Conditions. J Pediatr. 2017 10; 189:222-226.e1. PubMed

  • Sparks TN, Thao K, Norton ME. Mosaic trisomy 16: what are the obstetric and long-term childhood outcomes? Genet Med. 2017 10; 19(10):1164-1170. PubMed

  • Sparks TN, Norton ME, Flessel M, Goldman S, Currier RJ. Observed Rate of Down Syndrome in Twin Pregnancies. Obstet Gynecol. 2016 11; 128(5):1127-1133. PubMed

  • Sparks TN, Shaffer BL, Page J, Caughey AB. Gastroschisis: mortality risks with each additional week of expectant management. Am J Obstet Gynecol. 2017 Jan; 216(1):66.e1-66.e7. PubMed

  • Henry D, Gonzalez JM, Harris IS, Sparks TN, Killion M, Thiet MP, Bianco K. Maternal arrhythmia and perinatal outcomes. J Perinatol. 2016 10; 36(10):823-7. PubMed

  • Sparks TN, Nakagawa S, Gonzalez JM. Hypertension in dichorionic twin gestations: how is birthweight affected? J Matern Fetal Neonatal Med. 2017 Feb; 30(4):380-385. PubMed

  • Sparks TN, Griffin E, Page J, Pilliod R, Shaffer BL, Caughey AB. Down syndrome: perinatal mortality risks with each additional week of expectant management. Prenat Diagn. 2016 Apr; 36(4):368-74. PubMed

  • Sparks TN, Yeaton-Massey A, Granados JM, Handler SJ, Meyer M, Caughey AB. How do maternal views of delivery outcomes vary by demographics and preferred mode of delivery? Am J Perinatol. 2015 Jul; 32(8):741-6. PubMed

  • Sparks TN, Yeaton-Massey A, Granados JM, Handler SJ, Meyer MR, Caughey AB. Preference toward future mode of delivery: how do antepartum preferences and prior delivery experience contribute? J Matern Fetal Neonatal Med. 2015; 28(14):1673-8. PubMed

  • Delaney S, Shaffer BL, Cheng YW, Vargas J, Sparks TN, Paul K, Caughey AB. Predictors of cesarean delivery in women undergoing labor induction with a Foley balloon. J Matern Fetal Neonatal Med. 2015 Jun; 28(9):1000-4. PubMed

  • Yeaton-Massey A, Wong L, Sparks TN, Handler SJ, Meyer MR, Granados JM, Stasenko M, Sit A, Caughey AB. Racial/ethnic variations in perineal length and association with perineal lacerations: a prospective cohort study. J Matern Fetal Neonatal Med. 2015 Feb; 28(3):320-3. PubMed

  • Kim LH, Cohan DL, Sparks TN, Pilliod RA, Arinaitwe E, Caughey AB. The cost-effectiveness of repeat HIV testing during pregnancy in a resource-limited setting. J Acquir Immune Defic Syndr. 2013 Jun 01; 63(2):195-200. PubMed

  • Sparks TN, Cheng YW, Phan N, Caughey AB. Does risk of preeclampsia differ by twin chorionicity? J Matern Fetal Neonatal Med. 2013 Sep; 26(13):1273-7. PubMed

  • Cheng YW, Sparks TN, Laros RK, Nicholson JM, Caughey AB. Impending macrosomia: will induction of labour modify the risk of caesarean delivery? BJOG. 2012 Mar; 119(4):402-9. PubMed

  • Ohno MS, Sparks TN, Cheng YW, Caughey AB. Treating mild gestational diabetes mellitus: a cost-effectiveness analysis. Am J Obstet Gynecol. 2011 Sep; 205(3):282.e1-7. PubMed

  • Stasenko M, Liddell J, Cheng YW, Sparks TN, Killion M, Caughey AB. Patient counseling increases postpartum follow-up in women with gestational diabetes mellitus. Am J Obstet Gynecol. 2011 Jun; 204(6):522.e1-6. PubMed

  • Solheim KN, Esakoff TF, Little SE, Cheng YW, Sparks TN, Caughey AB. The effect of cesarean delivery rates on the future incidence of placenta previa, placenta accreta, and maternal mortality. J Matern Fetal Neonatal Med. 2011 Nov; 24(11):1341-6. PubMed

  • Esakoff TF, Sparks TN, Kaimal AJ, Kim LH, Feldstein VA, Goldstein RB, Cheng YW, Caughey AB. Diagnosis and morbidity of placenta accreta. Ultrasound Obstet Gynecol. 2011 Mar; 37(3):324-7. PubMed

  • Sparks TN, Cheng YW, McLaughlin B, Esakoff TF, Caughey AB. Fundal height: a useful screening tool for fetal growth? J Matern Fetal Neonatal Med. 2011 May; 24(5):708-12. PubMed

  • Delaney S, Shaffer BL, Cheng YW, Vargas J, Sparks TN, Paul K, Caughey AB. Labor induction with a Foley balloon inflated to 30 mL compared with 60 mL: a randomized controlled trial. Obstet Gynecol. 2010 Jun; 115(6):1239-1245. PubMed

  • Esakoff TF, Cheng YW, Sparks TN, Caughey AB. The association between birthweight 4000 g or greater and perinatal outcomes in patients with and without gestational diabetes mellitus. Am J Obstet Gynecol. 2009 Jun; 200(6):672.e1-4. PubMed